Faced with the persistent threat of major animal epidemics such as African swine fever, disease prevention and control in large-scale livestock breeding is confronting unprecedented challenges. Traditional disinfection methods have numerous shortcomings in terms of disinfectant selection, dilution ratio, contact time and on-site implementation. These deficiencies not only compromise disinfection efficacy, but also pose health risks to animals and frontline workers. Prolonged use may even lead to environmental pollution and antimicrobial resistance. Against this backdrop, hypochlorous acid, a novel, safe, highly effective and eco-friendly disinfection agent, is gradually gaining traction in the breeding industry.